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Target intelligence / Profile preview
Tumor necrosis factor receptor superfamily member 16 (p75NTR)
- Target
- p75NTR
- Molecular classification
- TNF Receptor Superfamily, Receptor, Transmembrane glycoprotein
01
Overview
Tumor necrosis factor receptor superfamily member 16 (p75NTR) is a transmembrane glycoprotein and a member of the tumor necrosis factor receptor (TNFR) superfamily. It is also known as the low-affinity nerve growth factor receptor (LNGFR or NGFR). This receptor plays critical roles in nervous system development and function, influencing neuronal survival, apoptosis, axon guidance, and synaptic plasticity. Beyond neural functions, it regulates glucose metabolism. Therapeutic targeting is under investigation for various indications, including Alzheimer’s disease and neuropathies.
- Other names
- NGFRCD271LNGFRLow-affinity nerve growth factor receptor
02
Mechanism of action
Modulation of NFκB activation and JNK-mediated apoptosis
03
Biological functions
Neuronal differentiationNeuronal survivalApoptosisAxon guidanceSynaptic plasticityCell proliferationCell deathRegulation of glucose metabolismSignaling
04
Disease associations
Alzheimer’s DiseaseTraumatic Brain InjuryChemotherapy-Induced Peripheral NeuropathyDiabetic Neuropathic Foot UlcersNeurodegenerative diseaseNeuropathies
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