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Target intelligence / Profile preview
Low Affinity Neurotrophin Receptor p75NTR (p75NTR)
- Target
- p75NTR
- Molecular classification
- Receptor, Type I transmembrane protein
01
Overview
The low affinity neurotrophin receptor p75NTR is a type I transmembrane protein that binds all neurotrophins with low affinity. It plays diverse roles including regulation of cell death and survival, neurite outgrowth, synaptic plasticity, and scar formation after injury. p75NTR's intracellular death domain serves as a hub for interacting with adaptor proteins to activate signaling pathways such as NF-kB and RhoA. It is implicated in neurodegenerative diseases, cancers, and tissue injury, making it a potential therapeutic target.
- Other names
- NGFRLow-affinity nerve growth factor receptorNerve growth factor receptorGp80-LNGFRCD271p75 ICD[7]
02
Mechanism of action
Inhibition of p75NTR function
03
Biological functions
Regulation of cell death/apoptosisRegulation of cell survivalNeurite outgrowthSynaptic plasticityScar formation after injuryEnergy expenditure/metabolism regulationHypoxic response adaptationMechanotransduction
04
Disease associations
Neurodegenerative diseasesAlzheimer's diseaseAmyotrophic Lateral Sclerosis/Motor Neuron DiseaseCancersTissue injury
05
Safety considerations
Modulating neuronal damage post-injurySlowing progression of degenerative diseases
06
Biomarkers
Extracellular domain of p75NTR as a biomarker for disease progression in neurodegenerative diseases
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