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Target intelligence / Profile preview
Low-Density Lipoprotein Cholesterol (LDL)
- Target
- LDL
- Molecular classification
- Lipoprotein
01
Overview
Low-density lipoprotein cholesterol (LDL cholesterol) is a type of lipoprotein particle found in the blood that transports cholesterol to cells throughout the body. Elevated levels of LDL cholesterol are associated with an increased risk for atherosclerosis and cardiovascular diseases. While essential for normal physiology, high LDL concentrations promote arterial plaque formation.
- Other names
- LDL-CLDL CholesterolBad Cholesterol
02
Mechanism of action
Various mechanisms including inhibition of cholesterol synthesis (statins), reduction of cholesterol absorption (ezetimibe), and increased LDL receptor expression (PCSK9 inhibitors).
03
Biological functions
Cholesterol transportFat transportDelivery of cholesterol to cellsCell membrane synthesis
04
Disease associations
AtherosclerosisCoronary artery diseaseHeart attackStrokePeripheral artery diseaseCardiovascular disease
05
Safety considerations
Elevated levels associated with increased cardiovascular riskLowering LDL-C too much might have unknown consequences
06
Interacting drugs
Statins
6 more in the full profile.
07
Biomarkers
LDL-C levels
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