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Target intelligence / Profile preview
Low-Density Lipoprotein Oxidation Pathway (oxLDL Pathway)
- Target
- oxLDL Pathway
- Molecular classification
- Pathway, Lipoprotein Metabolism, Oxidative Stress
01
Overview
The low-density lipoprotein (LDL) oxidation pathway encompasses the biochemical processes by which native LDL particles undergo oxidative modification, resulting in oxidized LDL (oxLDL). This process is central to the development of atherosclerosis and cardiovascular disease. Enzymatic and non-enzymatic mechanisms contribute to LDL oxidation, leading to modification of ApoB-100 and formation of reactive aldehydes. oxLDL is avidly taken up by macrophages, leading to foam cell formation and plaque buildup in arteries.
- Other names
- LDL OxidationOxidized LDL FormationLDL Oxidative Modification
02
Mechanism of action
N/A - This is a pathway, not a single target.
03
Biological functions
Lipid transportOxidationInflammationAtherogenesis
04
Disease associations
AtherosclerosisCardiovascular DiseaseHyperlipidemia
05
Safety considerations
Potential for antioxidants to have pro-oxidant effects under certain conditionsComplexity of modulating oxidative processes in vivo
06
Interacting drugs
Antioxidants (e.g., Vitamin E)
1 more in the full profile.
07
Biomarkers
oxLDL levelsMalondialdehyde (MDA)ApoB-100 modificationsCeroid
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