Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Low-density lipoprotein receptor (LDLR)
- Target
- LDLR
- Molecular classification
- Receptor, Cell-surface glycoprotein
01
Overview
The low-density lipoprotein receptor (LDLR) is a cell-surface glycoprotein that plays a central role in cholesterol homeostasis by mediating the endocytosis of cholesterol-rich low-density lipoproteins (LDL) from the bloodstream into cells. It is encoded by the *LDLR* gene located on chromosome 19 in humans. Mutations in *LDLR* disrupt its synthesis, processing, or function—leading to familial hypercholesterolemia: an inherited disorder characterized by elevated blood cholesterol levels and increased risk for premature cardiovascular disease due to impaired clearance of LDL-cholesterol from circulation. All currently approved lipid-lowering therapies aim—directly or indirectly—to increase hepatic expression or activity of functional LDLRs as a means to lower circulating cholesterol levels and reduce cardiovascular risk.
- Other names
- LDL receptor
02
Mechanism of action
Increase hepatic expression or activity of functional LDLRs
03
Biological functions
Receptor-mediated endocytosisCholesterol homeostasisLipoprotein uptake
04
Disease associations
Familial hypercholesterolemiaCardiovascular diseaseMyocardial infarctionCoronary artery disease
05
Safety considerations
Side effects related to lipid-lowering therapies
06
Interacting drugs
Lipid-lowering therapies (statins, PCSK9 inhibitors, etc.)
07
Biomarkers
Plasma LDL-cholesterol levels
Beyond the preview
Go deeper on Low-density lipoprotein receptor (LDLR).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Low-density lipoprotein receptor (LDLR).