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Low-density lipoprotein receptor class A domain-containing protein 1 (LDLRAD1)
- Target
- LDLRAD1
- Molecular classification
- Other (belongs to the LDL receptor family, but is not itself classified as a classical receptor, enzyme, transporter, transcription factor, or ion channel)[5]
01
Overview
Low-density lipoprotein receptor class A domain-containing protein 1 (LDLRAD1) is a member of the LDL receptor family that is predicted to be membrane-localized and structurally contains a class A (complement-type ligand binding) domain. While its precise molecular and physiological roles remain uncharacterized, genetic studies have implicated LDLRAD1 in disease susceptibility, including risk for breast cancer, coronary heart disease, and Parkinson’s disease, suggesting potential relevance in diverse biological processes and disease mechanisms. However, its function, mechanisms of action, and druggability have not yet been established in the literature[2][3][5].
- Other names
- LDLRAD1low density lipoprotein receptor class A domain containing 1low-density lipoprotein receptor class A domain-containing protein 1
02
Biological functions
Other (predicted to function in membrane-associated processes and possibly in modulation of signal transduction; exact function unknown)[2][5]
03
Disease associations
Cancer (candidate gene for breast cancer susceptibility)[3]Cardiovascular disease (associated with coronary heart disease risk)[3]Neurodegenerative disease (candidate gene in the PARK10 locus related to Parkinson’s disease)[3]
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