Low-density lipoprotein receptor-related protein 10 (LRP10)

Low-density lipoprotein receptor-related protein 10 (LRP10) is a single-pass type I transmembrane receptor that is part of the LDL receptor gene superfamily, specifically an orphan LRP subfamily with LRP3 and LRP12[1][2][3]. Its structure includes extracellular CUB domains, LDL ligand-binding repeats, a transmembrane domain, and a large cytoplasmic tail with acidic dileucine motifs enabling interaction with clathrin adaptor proteins and regulating trafficking between the trans-Golgi network and endosomes[1][2]. LRP10 is involved in the post-translational regulation of IL7R on T-cells, suppressing their homeostatic expansion[2]. In neurons, LRP10 controls the trafficking and processing of amyloid precursor protein (APP), influencing pathways relevant to Alzheimer’s disease[1]. Knockout and mutational studies suggest roles in neurodegeneration, immune cell development, and possibly tumor surveillance[1][2]. No drugs currently target LRP10 directly.

Other names

LDL receptor-related protein 10LRP10LRP-10LRP9MSTP087MST087SP220UNQ389/PRO724DKFZP564C1940MGC8675

Not directly targeted by clinically approved drugs; mechanistic studies suggest it can regulate protein trafficking (APP, IL7R), which may influence amyloid plaque formation and immune function indirectly[1][2][3].