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Target intelligence / Profile preview
Low Density Lipoprotein Receptor-Related Protein 5 (LRP5)
- Target
- LRP5
- Molecular classification
- Receptor, Transmembrane protein
01
Overview
Low-density lipoprotein receptor-related protein 5 (LRP5) is a transmembrane receptor that functions as a co-receptor in the canonical Wnt signaling pathway. It plays critical roles in bone formation, eye development, glucose metabolism, and cholesterol homeostasis, and is implicated in cancer progression.
02
Mechanism of action
Wnt signaling modulation
03
Biological functions
Wnt signalingBone homeostasisCholesterol metabolismGlucose-induced insulin secretionCell proliferation
04
Disease associations
Osteoporosis pseudoglioma syndromeHigh-bone-mass disordersDiabetes mellitusCancer
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