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Target intelligence / Profile preview
Low-density Lipoprotein Receptor-Related Protein 6 (LRP6)
- Target
- LRP6
- Molecular classification
- Receptor, LDL Receptor Family, Transmembrane Protein
01
Overview
Low-density lipoprotein receptor-related protein 6 (LRP6) is a single-pass transmembrane cell surface protein and a member of the low-density lipoprotein (LDL) receptor gene family. It functions as a co-receptor for Wnt proteins in canonical Wnt/β-catenin signaling, regulating cell differentiation, proliferation, and embryonic development. It also mediates endocytosis and LDL uptake. Mutations in LRP6 are associated with metabolic disturbances, including hyperlipidemia and increased risk for metabolic syndrome and cardiovascular disease.
02
Mechanism of action
Wnt signaling modulation
03
Biological functions
Signal transductionEndocytosisCell differentiationCell proliferationEmbryonic developmentBone formationLipid homeostasis
04
Disease associations
Metabolic syndromeCardiovascular diseaseAtherosclerosisHyperlipidemiaNon-alcoholic fatty liver disease (NAFLD)Obesity-related disordersCancer
05
Safety considerations
Potential for off-target effects due to widespread Wnt signaling involvementCardiovascular complications
06
Biomarkers
LDL cholesterol levelsTriglyceride levelsFasting glucose levels
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