Low Expression Noncoding RNA in Gastric Adenocarcinoma (LENGA)

LENGA, also known as Low Expression Noncoding RNA in Gastric Adenocarcinoma (RRAGC Divergent Transcript, RRAGC-DT), is a long noncoding RNA found to be significantly downregulated in gastric cancer tissues compared with adjacent normal tissue. Its low expression is associated with more aggressive tumor behavior and shorter patient survival. Overexpression of LENGA suppresses gastric cancer cell proliferation and metastasis both in vitro and in vivo. Mechanistically, LENGA acts as an RNA scaffold facilitating the interaction between BRD7 and TP53, enhancing the transcriptional activation of p53 pathway genes including CDKN1A, which in turn suppresses tumorigenic processes. Its function as a tumor suppressor and its downregulation in gastric cancer make it a promising prognostic biomarker and a potential, though as yet unproven, focus for therapeutic development[1][2][3].

Other names

LENGALow Expression Noncoding RNA in Gastric AdenocarcinomaRRAGC Divergent TranscriptRRAGC-DT

Not applicable. No approved or experimental drugs act on this molecule currently.