Low Molecular Mass Polypeptide 7 (LMP7)

Immunoproteasome subunit LMP7, also known as β5i or PSMB8, is a catalytically active component of the immunoproteasome—a specialized form of the proteasome complex predominantly found in cells of hematopoietic origin and induced by inflammatory cytokines such as interferon-gamma (IFNγ). It facilitates degradation of ubiquitin-labeled proteins and generates peptides with hydrophobic C termini suitable for binding to MHC class I molecules, enhancing antigen presentation to cytotoxic CD8+ T cells. Inhibition or deficiency leads to altered immune responses, making it a therapeutic target for autoimmune and inflammatory diseases.

Other names

β5iPSMB8

Selective inhibition of LMP7 catalytic activity