LOXL1 antisense RNA 1 (LOXL1-AS1)

LOXL1 antisense RNA 1 (LOXL1-AS1) is a long non-coding RNA (lncRNA) transcribed antisense to the LOXL1 gene, located on chromosome 15q24.1[4]. Unlike protein-coding genes, LOXL1-AS1 does not encode a protein but instead modulates cellular processes by regulating gene expression at the RNA level. LOXL1-AS1 is dysregulated in various diseases, notably in different cancers and some non-malignant conditions (such as osteoarthritis and pseudoexfoliation glaucoma)[1][3][5]. In many cancers, LOXL1-AS1 acts as an oncogenic lncRNA, promoting proliferation, migration, metastasis, and epithelial-mesenchymal transition, while inhibiting apoptosis[1][2][4][5]. Mechanistically, it functions predominantly as a miRNA sponge, binding multiple microRNAs (including miR-761, miR-423-5p, miR-21, miR-28-5p, and others) and thereby preventing them from repressing their target mRNAs[1][5]. LOXL1-AS1 also interacts with proteins such as hnRNPL, affecting global gene expression, extracellular matrix remodeling, and cell contractility[3]. Upregulation of LOXL1-AS1 is associated with adverse prognosis and disease progression, and it is increasingly studied as a candidate molecular biomarker and potential therapeutic target, though no drugs currently target it directly[1][2][3][4][5].

Other names

LOXL1 antisense RNA 1 (non-protein coding)lncRNA LOXL1-AS1Lysyl oxidase-like 1-antisense 1

MicroRNA (miRNA) sponge/competitive endogenous RNA (ceRNA) activity, Decoy for transcription factors and protein regulators, Indirect modulation of signaling pathways (e.g., PI3K-AKT, MEK/ERK)