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LRAT domain containing 2 (LRATD2)
- Target
- LRATD2
- Molecular classification
- Other (LRAT superfamily; contains LRAT domain; not currently classified as a receptor, enzyme, transporter, etc.)
01
Overview
LRAT domain containing 2 (LRATD2), also known as FAM84B or breast cancer membrane protein 101, encodes a protein that contains an LRAT (lecithin retinol acyltransferase) domain but is not a known enzyme or receptor. It is a protein-coding gene found at the plasma membrane and cytoplasm and is implicated in cancer pathogenesis, especially breast and prostate cancer. LRATD2 promotes cell proliferation, potentially through cell cycle-related pathways, and may serve as a prognostic biomarker in several tumors. Although it is considered a putative therapeutic target due to its cancer associations, there are currently no approved drugs specifically targeting LRATD2, and its precise molecular role in disease remains under investigation.
- Other names
- Protein LRATD2BCMP101FAM84BNSE2Breast cancer membrane protein 101Neurological/sensory 2Breast cancer membrane-associated protein 101Family with sequence similarity 84 member B
02
Mechanism of action
Not established; no drugs targeting LRATD2 with documented mechanism of action
03
Biological functions
Protein bindingCell proliferation (notably promotes proliferation in certain cancer cell types)Possible roles in membrane-associated processes
04
Disease associations
Cancer (specifically associated with breast cancer and prostate cancer)Potential prognostic marker in multiple cancers, including bladder, breast, colon, kidney, and lung carcinomas
05
Biomarkers
Prognostic marker in several cancers (bladder urothelial carcinoma, breast invasive carcinoma, colon adenocarcinoma, kidney renal clear cell carcinoma, lung adenocarcinoma)
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