LRRC8C divergent transcript (LRRC8C-DT)

LRRC8C divergent transcript (LRRC8C-DT) is annotated as a divergent, likely non-coding transcript neighboring the LRRC8C gene[4]. There is currently no substantive evidence that LRRC8C-DT encodes a functional protein product or has established biological, pharmacological, or disease relevance. Importantly, this should not be confused with the protein-coding gene Leucine-rich repeat-containing protein 8C (LRRC8C), which is a subunit of the volume-regulated anion channel (VRAC) and has been studied in cell biology and disease[1][2][3][5]. LRRC8C-DT itself has no reported molecular function, role as a drug target, biomarker utility, or safety relevance in the biomedical literature or curated gene/protein databases[4]. If your intent was to target the VRAC protein subunit (LRRC8C), please clarify, as the information here refers strictly to the divergent transcript LRRC8C-DT, which lacks demonstrated molecular or therapeutic importance.

Other names

FLJ27354LRRC8C-DT