LUC7-like pre-mRNA splicing factor family member (LUC7L (for LUC7-like protein 1), LUC7L2 (for LUC7-like protein 2), LUC7L3 (for LUC7-like protein 3))

The LUC7-like family comprises three human proteins (LUC7L, LUC7L2, LUC7L3) that are conserved nuclear zinc finger-containing splicing factors. They are fundamental components of the spliceosome and function primarily to regulate pre-mRNA splicing by interacting with small nuclear RNAs (notably U1 snRNA) and specifying 5' splice-site selection. Each member has a somewhat distinct binding pattern on pre-mRNAs and tissue-specific expression, enabling fine-tuned regulation of constitutive and alternative splicing. LUC7-like proteins are essential for normal cell function, differentiation, and play a critical role in hematopoietic cells. Dysfunction or loss, especially of LUC7L2, is linked to impaired splicing and certain leukemias.

Other names

LUC7LLUC7L2LUC7L3LUC7 familyLUC7-like splicing factors

Modulation of pre-mRNA splicing, mainly by influencing recognition and usage of 5' splice sites when targeted by splicing regulatory molecules