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Target intelligence / Profile preview
Lung cancer associated long non-coding RNA 1 (LCAL1)
- Target
- LCAL1
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
Lung cancer associated long non-coding RNA 1 (LCAL1) is a long intergenic non-coding RNA located on chromosome 6q14.1, producing a three-exon transcript. LCAL1 is highly and specifically upregulated in lung adenocarcinoma and squamous cell carcinoma compared to normal lung tissue. Experimental studies show that LCAL1 regulates cellular proliferation: siRNA-mediated knockdown decreases cell growth, while overexpression increases proliferation in both cancer and non-cancer cell models. LCAL1 is enriched in the nucleus and associated with regulatory activities in its promoter region, typical for lncRNAs involved in gene regulation. Its tissue-specific expression and role in cancer cell growth suggest it may function both as a biomarker and a potential therapeutic target, although no known drugs currently target LCAL1 directly.
- Other names
- LCAL1lung cancer associated lncRNA 1onco-lncRNA-27
02
Biological functions
Cell proliferationGene regulation
03
Disease associations
CancerLung cancer (adenocarcinoma and squamous cell carcinoma subtypes)
04
Safety considerations
Therapeutic challenges include lack of drugs targeting lncRNAs directly and unknown safety profile for manipulation of LCAL1.Off-target effects and the challenge of delivering RNA-targeted therapies in vivo
05
Biomarkers
LCAL1 itselfSubtype-specific molecular signatures using LCAL1 for lung cancer stratification
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