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Target intelligence / Profile preview
Lung cancer-associated serum protein 1 receptor (LASEPR)
- Target
- LASEPR
- Molecular classification
- Receptor, Surface protein
01
Overview
Lung cancer-associated serum protein 1 receptor (LASEPR) is a 50-kDa cell surface receptor that interacts with the secreted protein LASEP1 (Lung cancer-associated serum protein 1). This interaction is reported to promote the growth and proliferation of lung cancer cells through an autocrine signaling mechanism. LASEPR is frequently overexpressed in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), where its activation is linked to poor patient prognosis. Experimental studies have shown that silencing LASEPR using siRNA or neutralizing its ligand LASEP1 with monoclonal antibodies significantly inhibits tumor cell growth and induces apoptosis. Consequently, the LASEP1-LASEPR axis is considered a potential therapeutic target and a source of serological biomarkers for the diagnosis and monitoring of lung cancer progression.
- Other names
- LASEPRLASEP1 receptorLung cancer-associated serum protein 1 receptor
02
Mechanism of action
Neutralization of ligand-receptor interaction to inhibit autocrine growth signaling
03
Biological functions
Cell proliferationCell growthAutocrine signalingSignal transduction
04
Disease associations
Lung cancerNon-small cell lung cancerSmall cell lung cancer
05
Safety considerations
Potential for off-target effects if expressed in normal tissuesTherapeutic challenges related to antibody delivery and receptor specificity
06
Interacting drugs
Anti-LASEP1 monoclonal antibodies (experimental)
1 more in the full profile.
07
Biomarkers
LASEP1 serum levelsLASEP1 tissue expression
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