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Target intelligence / Profile preview
Luteinizing Hormone (LH)
- Target
- LH
- Molecular classification
- Glycoprotein hormone, Gonadotropin
01
Overview
Luteinizing hormone (LH) is a glycoprotein gonadotropin hormone produced by the anterior pituitary gland. In females, it triggers ovulation and stimulates the corpus luteum to produce progesterone. In males, it stimulates Leydig cells to produce testosterone. LH is essential for normal sexual development and reproductive function in both sexes. Its release is regulated by GnRH from the hypothalamus and it acts through the luteinizing hormone receptor (LHR).
02
Mechanism of action
LH binds to the luteinizing hormone receptor (LHR), a G protein-coupled receptor, activating intracellular signaling cascades that lead to steroidogenesis, oocyte maturation/ovulation, and male sex differentiation.
03
Biological functions
Triggers ovulationStimulates corpus luteum formationProgesterone productionRegulates menstrual cycleTestosterone synthesisSpermatogenesisSexual development
04
Disease associations
InfertilityReproductive system dysfunctionsPituitary gland disorders
05
Safety considerations
Ovarian hyperstimulation syndrome (OHSS)Multiple pregnanciesHormonal imbalances
06
Interacting drugs
GnRH analogs (agonists/antagonists)
2 more in the full profile.
07
Biomarkers
LH levels (blood/urine) for ovulation predictionLH levels (blood/urine) for assessing infertilityLH levels (blood/urine) for monitoring pituitary function
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