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Target intelligence / Profile preview
Luteinizing Hormone Receptor (LHR)
- Target
- LHR
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The luteinizing hormone receptor (LHR), also known as the luteinizing hormone/choriogonadotropin receptor (LHCGR), is a member of the glycoprotein hormone receptor subfamily within the superfamily of G protein-coupled receptors (GPCRs). It is essential for reproductive processes, including gonadal steroidogenesis, oocyte maturation and ovulation in females, and male sex differentiation. Mutations or dysregulation can result in various pathologies, including infertility, precocious puberty, and certain neoplasms.
- Other names
- Luteinizing hormone/choriogonadotropin receptorLHCGRLutropin/choriogonadotropin receptor
02
Mechanism of action
Ligand binding induces conformational change, activates G proteins (primarily Gs), leading to increased cAMP production and downstream signaling cascades.
03
Biological functions
SteroidogenesisOocyte maturationOvulationLeydig cell functionMale sex differentiationSignal transduction
04
Disease associations
InfertilityPrecocious pubertyOvarian cancerDisorders of sexual developmentEndometrial carcinoma
05
Safety considerations
Off-target toxicity of cytotoxic LHR analoguesPotential for constitutive activation leading to precocious puberty
06
Interacting drugs
LH
2 more in the full profile.
07
Biomarkers
LHR expression in ovarian cancerLHR expression in endometrial carcinoma
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