Luteinizing hormone subunit beta (LHB)

Luteinizing hormone subunit beta (LHB) is a protein encoded by the LHB gene and forms the beta subunit of luteinizing hormone (LH), a glycoprotein hormone secreted by the anterior pituitary gland[1][2][5]. The functional LH hormone is a heterodimer composed of a common alpha subunit and a hormone-specific beta subunit that confers biological specificity[2][5]. LH plays a central role in reproductive physiology by stimulating steroidogenesis in the ovaries and testes, thus promoting ovulation in females and spermatogenesis in males[2][5]. Mutations in the LHB gene are linked to hypogonadotropic hypogonadism, infertility, and certain disorders of sexual development[2]. LHB is clinically relevant in reproductive endocrinology and is a target for fertility drugs and hormone replacement therapies[2][5].

Other names

Lutropin subunit betaLH-BLSH-BLSH-betaLSH-βLuteinizing hormone betaLutropin beta chainInterstitial cell stimulating hormone beta chainCGB4hLHBHH23LH betaLH βluteinizing hormone subunit βluteinizing hormone βLUTROPINAC151602.1Gm29035Gm683LOC100040019LOC100045896

Mimicry or replacement of endogenous LH to stimulate gonadal steroidogenesis; Stimulation of ovulation or spermatogenesis