Luteolin

Luteolin is a naturally occurring flavone found in a wide range of plants, including celery, parsley, broccoli, and various medicinal herbs (PubChem, CID 5280445). It is important to note that Luteolin is a small molecule bioactive compound (a phytochemical) rather than a biological target, such as a receptor, enzyme, or transporter, that therapeutic drugs are typically designed to modulate. Luteolin is widely recognized for its potent antioxidant and anti-inflammatory properties, which it exerts by scavenging reactive oxygen species and inhibiting pro-inflammatory mediators such as COX-2 and NF-κB (NIH, PMC2615542). In oncology research, Luteolin has demonstrated the ability to inhibit tumor growth, suppress angiogenesis, and sensitize cancer cells to traditional chemotherapeutic agents like cisplatin by modulating the PI3K/Akt and MAPK signaling pathways (PubMed, 29653245). While it holds significant therapeutic potential as a lead compound or dietary supplement, its application in clinical settings is currently hindered by its poor pharmacokinetic profile and potential for metabolic interference with other medications.

Other names

3',4',5,7-TetrahydroxyflavoneLuteolineDigitoflavoneCyanidenon 1470

Luteolin acts as a multi-target bioactive ligand that inhibits various enzymes such as phosphodiesterase 4 (PDE4), cyclooxygenase-2 (COX-2), and various protein kinases, while also modulating key signaling pathways like NF-κB, PI3K/Akt, and MAPK/ERK (NIH, PMC2615542; PubMed, 18992367).