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Lutetium-177-induced DNA Damage (Lu-177 DNA Damage)
- Target
- Lu-177 DNA Damage
- Molecular classification
- DNA Damage, Radioactive Decay Product, Radiation Therapy
01
Overview
Lutetium-177 (Lu-177) is a radioactive isotope used in targeted radionuclide therapy. Its therapeutic effect is primarily due to the emission of beta particles during its radioactive decay, which induces DNA damage in target cells. The beta particles have a short tissue penetration range, allowing for localized irradiation and minimizing damage to surrounding healthy tissues. This localized deposition causes double-strand breaks and other forms of DNA damage within cancer cells, leading primarily to apoptosis or mitotic catastrophe.
- Other names
- Lu-177 Beta Particle EmissionLutetium-177 Radiotherapy EffectLu-177-induced double-strand breaks
02
Mechanism of action
Localized induction of double-strand breaks and other forms of DNA damage via beta particle emission from Lutetium-177, leading to apoptosis or mitotic catastrophe in target cells.
03
Biological functions
ApoptosisCell DeathDNA Damage ResponseAntitumor Activity
04
Disease associations
Cancer
05
Safety considerations
Off-target radiation exposureMyelosuppressionNephrotoxicitySalivary gland toxicity
06
Interacting drugs
Lu-177 DOTATATE
1 more in the full profile.
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