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Target intelligence / Profile preview
Lutropin-choriogonadotropic hormone receptor (LHCGR)
- Target
- LHCGR
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The lutropin-choriogonadotropic hormone receptor (LHCGR) is a transmembrane protein belonging to the G protein-coupled receptor (GPCR) superfamily. It is primarily expressed in the ovary and testis and serves as a receptor for luteinizing hormone (LH) and chorionic gonadotropins (hCG). Upon ligand binding, it activates G proteins, stimulating adenylate cyclase and triggering downstream signaling pathways essential for reproductive function. Mutations in LHCGR can lead to various health conditions, including familial male-limited precocious puberty and infertility disorders.
- Other names
- LH/CG-RLuteinizing hormone receptorLHRChorionic Gonadotropin ReceptorICSH ReceptorsHuman Chorionic Gonadotropin ReceptorshCGR
02
Mechanism of action
Agonist or antagonist binding modulates downstream signaling via G proteins and adenylate cyclase activation.
03
Biological functions
Signal transductionRegulation of ovulationRegulation of testosterone productionRegulation of Leydig cell development
04
Disease associations
Familial male-limited precocious pubertyInfertility
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