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Lymphatic System (N/A)
- Target
- N/A
- Molecular classification
- Organ System, Vascular Network
01
Overview
The lymphatic system is an organ system that plays a crucial role in fluid balance, fat absorption, and immune function. It consists of a network of vessels, nodes, and organs that transport lymph, a clear fluid containing white blood cells, throughout the body. It is not a single molecular target, but rather a complex system with various components that can be targeted for therapeutic intervention in diseases such as cancer, lymphedema, and immune disorders.
- Other names
- LymphaticsLymphatic vasculatureLymphoid system
02
Mechanism of action
Varies depending on the specific drug and target within the system. Examples include: Inhibition of lymphatic vessel growth, modulation of immune cell activity, reduction of inflammation, blocking cancer cell migration.
03
Biological functions
Fluid homeostasisFat absorptionImmune surveillanceImmune responseAntigen transportLymphocyte trafficking
04
Disease associations
LymphedemaLymphatic filariasisLymphomaMetastasisImmunodeficiencyInflammation
05
Safety considerations
LymphedemaImmunosuppressionOff-target effects on immune cellsImpaired wound healingIncreased risk of infectionExacerbation of autoimmune diseases
06
Interacting drugs
Anti-cancer drugs (targeting metastasis)
2 more in the full profile.
07
Biomarkers
Lymph node sizeLymphocyte countsLYVE-1 expressionVEGFR3 expressionPodoplanin expressionPresence of cancer cells in lymph nodes
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