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Lymphatic Vessels and Lymph Nodes
- Molecular classification
- Anatomical Structure, Vascular System, Immune Organ
01
Overview
Lymphatic vessels and lymph nodes are integral components of the lymphatic system, responsible for fluid balance, immune surveillance, and fat absorption. Lymphatic vessels collect and transport lymph, while lymph nodes filter lymph and initiate immune responses. Mapping these structures is crucial for cancer staging, sentinel node biopsy, immune monitoring, and targeted drug delivery. Key markers include LYVE-1, VEGFR-3, Podoplanin, and PNAd.
- Other names
- LymphaticsLymph NodesLymphatic System
02
Biological functions
Fluid BalanceImmune SurveillanceFat AbsorptionLymph TransportImmune Response InitiationAntigen PresentationFiltration
03
Disease associations
Cancer MetastasisLymphedemaLymphadenopathyImmune DeficiencyAutoimmune DiseaseInfection
04
Safety considerations
Lymphedema after lymph node removalRisk of infection following lymphatic disruptionOff-target effects of lymphatic-targeted therapiesImmune-related adverse events
05
Biomarkers
Lymph Node SizeLYVE-1 ExpressionVEGFR-3 ExpressionPodoplanin ExpressionPNAd ExpressionSR-B1 ExpressionCD206 ExpressionCD44 ExpressionDEC205 Expression
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