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Lymphocyte antigen 6 complex locus C1 (Ly6C)
- Target
- Ly6C
- Molecular classification
- Cell surface antigen, Glycosylphosphatidylinositol (GPI)-anchored protein, Member of Ly6/uPAR protein superfamily
01
Overview
Lymphocyte antigen 6 complex locus C1 (Ly6C) is a GPI-anchored cell-surface protein encoded by the Ly6c1 gene in mice. It belongs to the Ly6/uPAR superfamily, characterized by a conserved LU domain with multiple cysteine residues forming disulfide bridges and a “three-finger” protein topology similar to snake venom neurotoxins[5]. Ly6C is used extensively as a cell surface marker to distinguish subsets of immune cells, especially monocytes, T cells, and dendritic cells. High Ly6C expression (Ly6C^hi) marks pro-inflammatory monocytes, while low Ly6C (Ly6C^lo) defines patrolling monocytes. Ly6C is also expressed on subsets of memory CD8+ T cells and is upregulated during inflammation. Its main utility is in murine immunology and preclinical disease models for cell tracking and functional assays but it is not a druggable human therapeutic target[5][6][7].
- Other names
- Ly-6CLy-6C1AA682074AA959465Ly6c
02
Biological functions
Leukocyte differentiation markerImmune cell adhesion and migration, especially for monocytes, T cellsRegulation of immune cell subset function (distinguishes inflammatory and non-inflammatory monocytes, memory T cells)Cell-cell interaction
03
Disease associations
Inflammation (marker for inflammatory monocytes)Immune response modulation (mouse preclinical disease models)Potential roles in infection, autoimmunity, graft rejection (mouse studies), cancer (indirect, immune profiling)
04
Biomarkers
Marker for mouse monocyte subsets (Ly6C^hi for inflammatory, Ly6C^low for patrolling/non-inflammatory monocytes)Marker for memory CD8+ T cellsUsed in flow cytometry to distinguish lymphocyte subsets
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