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Target intelligence / Profile preview
Lymphocyte antigen 6 complex locus E (LY6E)
- Target
- LY6E
- Molecular classification
- GPI-anchored membrane protein, Ly6/uPAR superfamily
01
Overview
Lymphocyte antigen 6 complex, locus E (LY6E) is a GPI-anchored cell surface protein belonging to the Ly6/uPAR superfamily. It is involved in immune regulation, signal transduction, cell adhesion, drug resistance and modulation of HIV-1 infection. Overexpression is associated with poor prognosis in several cancers, particularly gastric cancer where it promotes cell survival, proliferation, and migration.
- Other names
- Ly86e
02
Biological functions
Immune regulationSignal transductionCell adhesionDrug resistanceCell proliferationCell survival
03
Disease associations
CancerInfectionPoor prognosis
04
Biomarkers
LY6E expression level in gastric cancer
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