Target intelligence / Profile preview

Lymphocyte antigen 6 complex locus E (LY6E)

Target: LY6E
Molecular classification: GPI-anchored membrane protein, Ly6/uPAR superfamily

Overview

Lymphocyte antigen 6 complex, locus E (LY6E) is a GPI-anchored cell surface protein belonging to the Ly6/uPAR superfamily. It is involved in immune regulation, signal transduction, cell adhesion, drug resistance and modulation of HIV-1 infection. Overexpression is associated with poor prognosis in several cancers, particularly gastric cancer where it promotes cell survival, proliferation, and migration.

Other names: Ly86e

Biological functions

Immune regulationSignal transductionCell adhesionDrug resistanceCell proliferationCell survival

Disease associations

CancerInfectionPoor prognosis

Biomarkers

LY6E expression level in gastric cancer

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