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Lymphocyte antigen 6 complex locus G (Ly-6G) (Ly-6G)
- Target
- Ly-6G
- Molecular classification
- Cell-surface antigen, GPI-anchored glycoprotein, Member of Ly-6/uPAR protein family
01
Overview
Lymphocyte antigen 6 complex locus G (Ly-6G) is a GPI-linked glycoprotein, 21–25 kDa, predominantly expressed on mature mouse neutrophils, serving as an essential marker for their identification and functional state; it plays roles in neutrophil migration through interaction with β2 integrins, in myeloid maturation, and in immune responses to infection and inflammation. Ly-6G is used as a target for experimental depletion of neutrophils in vivo, and its expression correlates with neutrophil aging and functional impairment in animal models. In humans, the functional homolog is CD177 and not Ly-6G. Members of the Ly-6 family are involved in diverse processes including cell proliferation, migration, and immune defense.
- Other names
- Ly6gLy-6GGr-1 (but Gr-1 recognizes both Ly-6G and Ly-6C)lymphocyte antigen 6 family member G
02
Mechanism of action
Anti-Ly-6G antibody binds Ly-6G on neutrophils, potentially leading to their depletion via immune-mediated mechanisms or blockade of migration/function
03
Biological functions
Neutrophil differentiation and identificationImmune responseRegulation of neutrophil migration (via interaction with β2 integrins)Myeloid cell maturationMarker for neutrophil function in aging, inflammation, and infection
04
Disease associations
Inflammation (role in migration and recruitment of neutrophils during inflammatory responses)Infection (marker and mediator of neutrophil responses to bacterial and parasitic infections)Cancer (Ly-6 family members implicated in tumorogenesis)Immune aging (marker for neutrophil functional decline in aging)
05
Safety considerations
In mouse models, anti-Ly-6G treatments can cause profound neutropenia, elevating risk of infection and impairing innate immunityNot directly applicable to humans due to lack of true Ly-6G homolog
06
Interacting drugs
anti-Ly-6G antibody (clone 1A8)
07
Biomarkers
Ly-6G expression level is used as a biomarker for neutrophil population quantification and functional statusmonitoring age-related decline in neutrophil function in mice
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