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Target intelligence / Profile preview
Lymphocyte Antigen 6 Complex Locus K (LY6K)
- Target
- LY6K
- Molecular classification
- LY6/uPAR superfamily, Transmembrane protein
01
Overview
Lymphocyte antigen 6 complex locus K (LY6K) is a member of the Ly6/uPAR superfamily and is classified as a cancer-testis antigen. It plays a role in male fertility and is overexpressed in various cancers, promoting tumorigenesis and progression. It is considered a potential target for immunotherapy.
- Other names
- Cancer-testis antigen
02
Mechanism of action
LY6K knockdown/silencing can suppress tumor cell proliferation and induce T-cell activation, stimulating anti-tumor immunity
03
Biological functions
Male fertility regulationSperm migration into oviductSperm binding to zona pellucidaFlagellated sperm motility regulationTumor growthImmune evasion
04
Disease associations
CancerNon-small cell lung carcinoma (NSCLC)Esophageal squamous cell carcinoma (ESCC)Breast cancerColorectal cancerBladder cancerEsophageal cancer
05
Biomarkers
Serum LY6K levelsCEACYFRA21-1
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