Target intelligence / Profile preview

Lymphocyte antigen 6 family member G6c (LY6G6C)

Target: LY6G6C
Molecular classification: Cell surface protein, Glycosylphosphatidylinositol (GPI)-anchored protein, Member of the Ly6/urokinase-type plasminogen activator receptor (uPAR) superfamily, Leukocyte antigen, Other

Overview

Lymphocyte antigen 6 family member G6c (LY6G6C) is a cell surface, glycosylphosphatidylinositol (GPI)-anchored protein that is part of the Ly6/urokinase-type plasminogen activator receptor (uPAR) superfamily and is located in the major histocompatibility complex (MHC) class III region on chromosome 6. LY6G6C is characterized by a cysteine-rich “three-finger” LU domain structure, typical of the LY6 family, and is found at the leading edges and filopodia of cells, highlighting its involvement in cell adhesion and migration. It is thought to play a multifaceted role in immune modulation, hematopoietic cell differentiation, and cell signaling, with potential ligands expressed on undifferentiated hematopoietic cells. Genetic association data suggest LY6G6C may be involved in complex disease processes including cancer and infection, but its precise biochemical mechanisms and therapeutic potential remain to be fully elucidated.

Other names: Lymphocyte antigen 6 complex locus protein G6cC6orf24G6CNG24UNQ1947/PRO4430lymphocyte antigen 6 complex, locus G6Clymphocyte antigen-6 G6C

Biological functions

Immune modulationSignal transductionCell adhesionCell migrationHematopoietic cell differentiationDevelopmental regulation

Disease associations

Cancer (implicated as a biomarker for poor prognosis and required for cancer progression in some contexts through the general LY6 family)Infection (e.g., potential association with HIV-related Kaposi’s sarcoma)Other (possible role in Lynch Syndrome 1)

Biomarkers

General LY6 family proteins are emerging as biomarkers in cancer for poor prognosis, but specific data for LY6G6C as a validated biomarker is lacking

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