Lymphocyte antigen 6 family member G6E (pseudogene) (LY6G6E)

Lymphocyte antigen 6 family member G6E (LY6G6E) is a **pseudogene** belonging to the Ly6/uPAR superfamily, located within the major histocompatibility complex (MHC) class III region on chromosome 6 in humans[1][2]. While it shares sequence similarity with functional LY6 family proteins—small, cysteine-rich, and often GPI-anchored immune cell surface molecules—LY6G6E does not encode a functional protein product in humans, and there is currently no evidence for direct biological activity, disease involvement, or pharmacological targeting of this locus[1][2]. The Ly6/uPAR protein family as a whole is known for diverse roles in cell signaling, immune cell differentiation, and cell surface interactions, but these functions are not currently attributed to the LY6G6E pseudogene[3][4]. **Note:** - There is a functional LY6G6E protein in *Mus musculus* (mouse), but in humans, the LY6G6E locus is annotated as a pseudogene and does not produce an active protein[1][2][6][10]. - Data sometimes confuses related functional family members (e.g., LY6G6D, LY6E), but direct information about human LY6G6E confirms its pseudogene annotation[1][2].

Other names

G6eLymphocyte antigen 6 complex, locus G6E (pseudogene)C6orf22Chromosome 6 open reading frame 22Lymphocyte antigen 6 complex, locus G6E, isoform CRA_aLymphocyte antigen 6 family member G6E

No mechanism of action for drugs against this pseudogene.