Lymphocyte cytosolic protein 2 (LCP2)

Lymphocyte cytosolic protein 2 (LCP2), also known as SLP-76, is an adaptor protein expressed primarily in hematopoietic cells. It serves as a critical scaffold organizing multi-protein complexes downstream of immune receptor engagement in T cells, natural killer cells, mast cells, and platelets. In T cells, LCP2 links phosphorylated receptors to downstream effectors, mediating signaling cascades that include calcium mobilization, MAP kinase activation, integrin clustering, and transcription factor activation, all essential to T cell activation and immune synapse formation. LCP2 also participates in platelet aggregation and vascular development, with genetic deficiency causing severe immunological and vascular defects in animal models. No small molecule or approved drug is currently known to selectively target LCP2 directly, but its expression and phosphorylation state are used as biomarkers of immune cell activation[1][2][3][4].

Other names

SLP-76SLP76SH2 domain-containing leukocyte protein of 76 kDaSLP-76 tyrosine phosphoprotein76 kDa tyrosine phosphoproteinSH2 domain-containing leukocyte protein of 76kDIMD81m1Khoetwm