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Lymphocyte Depletion (None)
- Target
- None
- Molecular classification
- Biological Process, Therapeutic Strategy
01
Overview
Lymphocyte depletion refers to the reduction or removal of lymphocytes, a type of white blood cell crucial for immune function, from circulation or specific tissues. This process is most commonly used as a form of immunosuppression in clinical settings, either by reducing circulating lymphocytes directly or by depleting T-cells from bone marrow preparations. The goal is often to suppress the immune response for therapeutic purposes, such as in transplantation, treatment of autoimmune diseases, or certain cancers.
02
Mechanism of action
Reduction/removal of circulating/tissue-resident lymphocytes through various mechanisms including antibody-mediated depletion and radiation-induced cell death.
03
Biological functions
ImmunosuppressionImmune system modulation
04
Disease associations
Transplant rejectionAutoimmune diseasesCancerLymphopeniaLymphocyte-depleted Hodgkin lymphoma (LDHL)
05
Safety considerations
Increased risk for infectionsPoorer outcomes in cancer patientsImpaired antitumor immunitySuboptimal cytokine responses (e.g., IL-15)Impaired lymphocyte reconstitution
06
Interacting drugs
Alemtuzumab
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