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Target intelligence / Profile preview
Lymphocyte differentiation antigen CD38 (CD38)
- Target
- CD38
- Molecular classification
- Transmembrane glycoprotein, Ectoenzyme
01
Overview
CD38 is a multifunctional transmembrane glycoprotein expressed on immune cells. It functions as both a cell surface antigen and an ectoenzyme, catalyzing the metabolism of NAD+ and regulating intracellular calcium mobilization. It is a therapeutic target in multiple myeloma, with anti-CD38 monoclonal antibodies like daratumumab and isatuximab approved for treatment. Altered CD38 expression/function is also implicated in autoimmune diseases.
02
Mechanism of action
Direct cytotoxicity against tumor cells, Fc-dependent mechanisms enhancing T/NK-cell-mediated immunity
03
Biological functions
Enzymatic conversion of NAD+ImmunomodulationCell adhesionCell signalingCalcium signalingB cell activation/differentiationT cell activation/proliferationChemotaxis
04
Disease associations
CancerAutoimmune diseasesInflammation
05
Safety considerations
Resistance mechanisms to anti-CD38 antibodiesDysregulated immune responses
06
Interacting drugs
Daratumumab
1 more in the full profile.
07
Biomarkers
CD38 expression level on malignant plasma cells
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