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Integrin Lymphocyte Function-Associated Antigen-1 (LFA-1)
- Target
- LFA-1
- Molecular classification
- Integrin, Cell adhesion molecule, Receptor
01
Overview
Integrin Lymphocyte Function-Associated Antigen-1 (LFA-1) is an α/β heterodimeric integrin receptor expressed on all leukocytes. It mediates leukocyte adhesion, migration, and activation by interacting with ICAMs and JAM-A. LFA-1 plays a crucial role in immune and inflammatory responses, including leukocyte emigration, T cell activation, and cytotoxic T cell-mediated killing. Deficiency leads to Leukocyte Adhesion Deficiency type I (LAD I). It is a therapeutic target for anti-inflammatory drugs.
- Other names
- CD11a/CD18ITGAL/ITGB2Lymphocyte function-associated antigen 1
02
Mechanism of action
Allosteric inhibition of ligand binding via conformational change
03
Biological functions
Leukocyte adhesionLeukocyte migrationT-cell activationCytotoxicityImmune responseInflammation
04
Disease associations
Leukocyte Adhesion Deficiency type I (LAD I)Inflammatory diseasesAutoimmune diseases
05
Safety considerations
Efalizumab withdrawal due to safety concerns
06
Interacting drugs
Efalizumab
1 more in the full profile.
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