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Lymphocyte Function-Associated Antigen 3 (LFA-3)

Target: LFA-3
Molecular classification: Immunoglobulin superfamily, Cell surface glycoprotein

Overview

Lymphocyte Function-Associated Antigen 3 (LFA-3), also known as CD58, is a widely expressed cell surface glycoprotein belonging to the immunoglobulin superfamily. It functions primarily as a ligand for the T lymphocyte CD2 molecule, mediating cell adhesion, costimulation, and signal transduction in immune responses. LFA-3 exists in transmembrane and GPI-anchored isoforms and is implicated in multiple sclerosis, cancer, and paroxysmal nocturnal hemoglobinuria.

Other names: CD58LFA3

Biological functions

Cell adhesionT cell activationCostimulationSignal transductionImmune responseRosetting

Disease associations

Multiple sclerosisCancerAutoimmune diseaseParoxysmal Nocturnal Hemoglobinuria

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