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Target intelligence / Profile preview
Lymphocyte-specific protein tyrosine kinase (Lck)
- Target
- Lck
- Molecular classification
- Src family non-receptor tyrosine kinase, Enzyme, Tyrosine Kinase
01
Overview
Lck is a Src family non-receptor tyrosine kinase crucial for T-cell development and activation. It initiates and propagates T-cell receptor (TCR) signaling by phosphorylating ITAMs on CD3/TCR complex subunits, leading to downstream signaling cascades and cytokine production. Lck activity is tightly regulated by phosphorylation at key residues (Y394, Y505) and conformational changes. Dysregulation of Lck can contribute to immune dysfunctions and hematological malignancies, making it a therapeutic target.
- Other names
- Tyrosine-protein kinase LCK
02
Mechanism of action
Inhibition of Lck kinase activity
03
Biological functions
T-cell receptor (TCR) signalingT-cell development and maturationIL-2 receptor signalingImmune responseSignal transductionCell proliferationCytokine production
04
Disease associations
Immune dysfunctionsHematological malignanciesChronic lymphocytic leukemiaFibrotic diseases
05
Safety considerations
Potential for immunosuppressionOff-target effects
06
Biomarkers
Lck expression/activity in chronic lymphocytic leukemia
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