Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Lymphotoxin-alpha (LT-α)
- Target
- LT-α
- Molecular classification
- Cytokine, Tumor Necrosis Factor Superfamily Ligand
01
Overview
Lymphotoxin-alpha (LT-α), also known as tumor necrosis factor-beta (TNF-β), is a cytokine belonging to the tumor necrosis factor superfamily. It plays a critical role in immune regulation, inflammation, and lymphoid organ development. It exists as a soluble homotrimer or forms heterotrimers with lymphotoxin-beta (LTβ). LTα interacts with several receptors, including TNFRSF1A/TNFR1, TNFRSF1B/TNFBR, HVEM/TNFRSF14, and LTβR/TNFRSF3, triggering signaling pathways involved in inflammation, apoptosis, immune cell activation, and tissue organization.
- Other names
- LT-alphaTNF-betaTNFBTNFSF1Tumor necrosis factor ligand superfamily member 1
02
Mechanism of action
Modulation of TNFRSF1A/TNFR1, TNFRSF1B/TNFBR, HVEM/TNFRSF14, and LTβR/TNFRSF3 signaling pathways.
03
Biological functions
Inflammation mediationApoptosis inductionSecondary lymphoid organogenesisImmune responseAntiviral activity
04
Disease associations
Autoimmunity (Rheumatoid Arthritis)Leprosy type IVMyocardial infarctionNon-Hodgkin's lymphomaPsoriatic arthritisCancer
05
Safety considerations
Overexpression or deficiency can influence cancer progression variably, sometimes promoting or inhibiting tumor growth/metastasis.Potential for off-target effects due to interactions with multiple receptors.Implication in autoimmune diseases; resistance to anti-TNF therapies may require targeting LTα instead.
06
Biomarkers
Genetic variations in LTA are linked to disease susceptibility and prognosis in myelodysplastic syndromes.
Beyond the preview
Go deeper on Lymphotoxin-alpha (LT-α).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Lymphotoxin-alpha (LT-α).