Target intelligence / Profile preview

Lyn kinase (None)

Target: None
Molecular classification: Enzyme, Protein tyrosine kinase, Src family kinase

Overview

Lyn kinase is a member of the Src family of non-receptor protein tyrosine kinases. It is highly expressed in hematopoietic cells and plays a crucial role in regulating both innate and adaptive immune responses. It acts as a "rheostat" controlling activation versus inhibition via phosphorylation of ITAMs and ITIMs. Dysregulation of Lyn is implicated in autoimmune diseases and certain leukemias, making it a therapeutic target.

Mechanism of action

HSP90 inhibitors destabilize Lyn kinase affecting growth/survival via NF-kappaB pathway inhibition.

Biological functions

Signal transductionImmune responseRegulation of B-cell signalingCell proliferationCalcium mobilizationCell differentiation

Disease associations

Autoimmune diseasesSystemic lupus erythematosus (SLE)Leukemia

Safety considerations

Modulation can lead to unintended consequences due to dual roles in activation and inhibition.

Interacting drugs

NVP-BEP800

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