LYR motif-containing protein 2 (LYRM2)

LYR motif-containing protein 2 (LYRM2) is a small, basic mitochondrial protein categorized within the LYR motif protein family, which is defined by a conserved Leu-Tyr-Arg (LYR) sequence near the N-terminus[2][3][1]. LYRM2 is involved in the assembly or regulation of mitochondrial complex I, a central enzyme in the mitochondrial respiratory chain and oxidative phosphorylation[5]. The loss or dysfunction of LYRM proteins can impact mitochondrial metabolism and has been linked to various disorders associated with mitochondrial dysfunction[1][3]. Although the exact function of LYRM2 is not fully defined, it is thought to affect complex I assembly indirectly, and there are indications it may play a role in DNA repair in higher eukaryotes[2]. LYRM2 has been associated with X-linked sideroblastic anemia with ataxia in humans[3]. Recent research suggests possible involvement in cancer through modulation of a signaling axis with Akt and complex I, highlighting potential relevance to tumor growth, but there is still no evidence of direct drug interactions or its use as a therapeutic target[6].

Other names

LYRM2DJ122O8.2LYR motif containing 2LYR motif-containing protein 2