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Target intelligence / Profile preview
LYRM4 antisense RNA 1 (LYRM4-AS1)
- Target
- LYRM4-AS1
- Molecular classification
- Long non-coding RNA, Antisense RNA
01
Overview
LYRM4 antisense RNA 1 (LYRM4-AS1) is a long non-coding antisense transcript located on chromosome 6p25.1 that regulates the expression of the adjacent LYRM4 gene, which encodes a protein involved in mitochondrial iron-sulfur cluster assembly[2][3]. LYRM4-AS1 has been implicated in cancer biology, with high levels predicting poor outcomes in glioma, and it may play roles in mitochondrial diseases through modulation of iron-sulfur cluster biogenesis[4][5]. It does not encode a protein nor serve as a drug target in current therapies.
- Other names
- LYRM4-AS1LYRM4 antisense RNA 1
02
Biological functions
Regulation of gene expression (as an antisense transcript, typically modulates expression of the sense gene LYRM4[2])
03
Disease associations
Cancer (high LYRM4-AS1 expression predicts poor prognosis in glioma and is associated with immune infiltration[4])Mitochondrial/metabolic disorders (associated with Combined Oxidative Phosphorylation Deficiency 19 through its relationship with LYRM4[3][5])
04
Biomarkers
high LYRM4-AS1 expression has been reported as a prognostic biomarker in glioma[4]
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