Lysine acetyltransferase 14 (KAT14)

Lysine acetyltransferase 14 (KAT14) is a nuclear enzyme encoded by the KAT14 gene in humans. It is a component of the ADA2A-containing ATAC histone acetyltransferase complex, involved in acetylating histones H3 and H4 to promote chromatin organization and transcriptional regulation. KAT14 plays a role as a scaffold supporting ATAC complex stability and is required for normal cell cycle progression, especially through the G1 and G2/M phases[1][5]. The protein binds to LIM domains of CSRP2 and has weak intrinsic acetyltransferase activity. Diseases associated with alterations in KAT14 include mitochondrial complex IV deficiency and Buruli ulcer, and it may participate in fibrotic disease mechanisms[1][6]. KAT14 is expressed predominantly in the nucleus with alternative spliced variants described[3]. *No specific drugs, biomarkers, or safety concerns are reported for KAT14 as of current publicly indexed sources.*

Other names

CSRP2-binding proteinCSRP2BPCRP2BPATAC2ADA2A-containing complex subunit 2dJ717M23.1PRO1194ATAC component 2 homolog (Drosophila)CRP2-binding partnerCysteine-rich protein 2-binding protein

Acetylation of lysines on core histones, modulating chromatin accessibility and transcription Effects may be mediated through targeting the ATAC complex for epigenetic modulation