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Target intelligence / Profile preview
Lysine Acetyltransferase 2B (KAT2B)
- Target
- KAT2B
- Molecular classification
- Enzyme, Histone modification, Transcription factor
01
Overview
Lysine acetyltransferase 2B (KAT2B), also known as P300/CBP-associated factor (PCAF), is a histone acetyltransferase enzyme and transcriptional coactivator. It plays a central role in regulating gene expression by modifying chromatin structure and interacting with various transcription factors, including p53. KAT2B functions as a histone acetyltransferase (HAT), primarily targeting core histones H3 and H4, leading to chromatin relaxation and promotion of transcriptional activation. It also acetylates non-histone proteins and plays a role in cell cycle regulation and development.
- Other names
- PCAFGCN5-related N-acetyltransferase
02
Mechanism of action
Inhibition of histone acetyltransferase activity
03
Biological functions
Transcriptional activationTranscriptional repressionCell cycle inhibitionDevelopmental processesChromatin remodeling
04
Disease associations
CancerDevelopmental disorders
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