Lysine acetyltransferase 5 (KAT5)

Lysine acetyltransferase 5 (KAT5), commonly known as TIP60, is a member of the MYST family of histone acetyltransferases that modifies chromatin structure by acetylating histone and non-histone proteins. KAT5 is crucial for regulating gene expression, DNA repair, apoptosis, cell cycle progression, and development. It performs its functions by catalyzing acetylation of specific lysine residues, thereby influencing the interactions between DNA and proteins involved in transcription and repair. KAT5 can interact with viral proteins, such as HIV-1 Tat, and is involved in regulating critical tumor suppressor pathways including p53. Altered KAT5 activity is implicated in various cancers, HIV infection, neurodegenerative disorders, and developmental abnormalities. Although no approved drugs directly target KAT5, it remains a key subject in epigenetic therapeutic research.

Other names

Histone acetyltransferase KAT5TIP60HTATIPHIV-1 Tat interactive proteinTIP55ESA1ZC2HC5PLIPcPLA2 interacting proteinTat-interacting protein 60 kDahistone acetyltransferase HTATIPprotein 2-hydroxyisobutyryltransferase KAT5protein acetyltransferase KAT5protein crotonyltransferase KAT5protein lactyltransferase KAT5

Inhibition of acetyltransferase activity; Modulation of chromatin remodeling; Regulation of DNA repair pathways; Induction of apoptosis via p53 acetylation