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Lysine Acetyltransferase 7 (KAT7)
- Target
- KAT7
- Molecular classification
- Enzyme, Histone acetyltransferase, MYST family histone acetyltransferase
01
Overview
Lysine Acetyltransferase 7 (KAT7), also known as HBO1 or MYST2, is a histone acetyltransferase enzyme that plays crucial roles in DNA replication, transcription regulation, and chromatin organization. It acetylates histones at lysine residues, particularly H4K5, H4K12, and H3K14, influencing gene expression and cellular processes. KAT7 is implicated in various diseases, including cancers like leukemia, osteosarcoma, lung cancer, and prostate cancer, as well as Ohdo Syndrome and pulmonary hypertension. It interacts with proteins like CDT1, Geminin, NLRP11 and Tip60 to carry out its functions. KAT7 is a potential therapeutic target, with inhibitors or modulators potentially offering novel approaches for treating these conditions.
- Other names
- HBO1MYST2
02
Mechanism of action
Histone acetylation inhibition (potential)
03
Biological functions
DNA replicationTranscription regulationChromatin organizationHistone acetylationRegulation of gene expressionCentromeric CENPA assembly
04
Disease associations
CancerLeukemiaAcute Myeloid Leukemia (AML)B-cell Acute Lymphoblastic LeukemiaOsteosarcomaLung CancerLung Adenocarcinoma (LUAD)Prostate CancerOhdo Syndrome, SBBYS variantPulmonary Hypertension
05
Safety considerations
Potential for off-target effects due to involvement in multiple cellular processesInhibition may affect normal cell function
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