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Target intelligence / Profile preview
Lysine Acetyltransferase p300 (EP300)
- Target
- EP300
- Molecular classification
- Enzyme, Histone modification, Transcription factor, Lysine Acetyltransferase
01
Overview
Lysine acetyltransferase p300 (EP300) is a transcriptional coactivator and histone acetyltransferase (HAT) that plays essential roles in chromatin remodeling and regulation of gene expression. It acetylates both histone and non-histone proteins, influencing various cellular processes including cell growth, differentiation, and development. Disruption or mutation of EP300 is associated with developmental disorders, neurological diseases, and cancer.
- Other names
- E1A-associated protein p300Histone Acetyltransferase p300p300
02
Mechanism of action
Inhibition of HAT activity or bromodomain binding
03
Biological functions
Chromatin remodelingGene regulationCell growthCell differentiationTranscription coactivator
04
Disease associations
CancerDevelopmental disordersNeurological diseasesNeurodegeneration
05
Safety considerations
Lack of selectivity between CBP/p300 for some inhibitors
06
Interacting drugs
Bromodomain inhibitors
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