Target intelligence / Profile preview

Lysine Demethylase 1A (LSD1)

Target: LSD1
Molecular classification: Enzyme, Histone modification, Amine oxidase

Overview

KDM1A/LSD1 is an essential epigenetic regulator controlling gene silencing via histone modification, crucial for development and cellular identity maintenance across multiple tissues. It functions as a flavin-dependent monoamine oxidase that demethylates mono- and di-methylated lysines on histone H3 at lysine 4 (H3K4me) and potentially lysine 9 (H3K9me).

Other names: KDM1A

Mechanism of action

Histone demethylation via flavin-dependent amine oxidase activity.

Biological functions

EmbryogenesisHematopoiesisNeuronal identity maintenanceTranscriptional regulationChromatin remodeling

Disease associations

NeuroblastomaIntellectual disabilityCleft palate syndromes

Safety considerations

Potential for oxidative DNA damage due to H2O2 production.

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