Lysine demethylase and nuclear receptor corepressor (HR)

Lysine demethylase and nuclear receptor corepressor (HR, commonly known as "hairless") is a transcriptional corepressor and histone lysine demethylase enzyme encoded by the HR gene. It is involved in hair growth and skin biology through control of gene expression via demethylation of mono- and dimethylated lysine 9 on histone H3 and by acting as a corepressor of nuclear receptors (e.g., thyroid hormone receptor, retinoic acid receptor-related orphan receptor, and vitamin D receptor). Mutations in HR cause hereditary hypotrichosis and other genetic hair loss syndromes, with two primary isoforms known in humans. Its canonical role is an epigenetic regulator affecting hair development, cell cycle, and neural processes

Other names

HRhairlessAUALUNCHSA277165HYPT4MUHHMUHH1lysine-specific demethylase hairlesshistone H3 dimethyl-L-lysine(9) demethylase hairlesshair growth associatedhairless homologprotein hairless

No targeted clinical drugs; mechanistically, drugs targeting this molecule would presumably act via inhibition or modulation of its demethylase activity or transcriptional corepressor function.