Target intelligence / Profile preview

Lysine Gingipain (Kgp)

Target: Kgp
Molecular classification: Enzyme, Cysteine protease

Overview

Lysine-specific gingipain (Kgp) is an essential cysteine protease virulence factor secreted by Porphyromonas gingivalis that targets peptide bonds after lysines within host proteins—facilitating bacterial colonization through adhesion domains while promoting tissue damage via broad-spectrum proteolysis. Its inhibition represents an attractive therapeutic target against periodontal disease caused by this pathogen.

Mechanism of action

Inhibition of cysteine protease activity

Biological functions

ProteolysisAdhesionImmune evasionTissue destruction

Disease associations

PeriodontitisCardiovascular diseaseLung diseaseInfection

Beyond the preview

Go deeper on Lysine Gingipain (Kgp).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Lysine Gingipain (Kgp).

Explore the full profile