Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Lysine Methyltransferase 2A (KMT2A)
- Target
- KMT2A
- Molecular classification
- Enzyme, Histone modification, Transcription factor
01
Overview
KMT2A is a histone methyltransferase enzyme that catalyzes the transfer of methyl groups to lysine 4 of histone H3 (H3K4), a key epigenetic mark associated with transcriptional activation. It is essential for regulating gene expression during early development and hematopoiesis. Chromosomal translocations involving KMT2A are implicated in various cancers, particularly acute leukemias.
- Other names
- MLLALL-1HRXMyeloid/Lymphoid or Mixed-Lineage Leukemia 1 (MLL1)Zinc Finger Protein HRX
02
Mechanism of action
H3K4 methyltransferase inhibitor (potential)
03
Biological functions
Gene expression regulationTranscription activationEpigenetic maintenanceChromatin activation
04
Disease associations
CancerLeukemia (ALL/AML)Wiedemann-Steiner SyndromeLung adenocarcinomaColon adenocarcinoma
05
Safety considerations
Off-target effects due to broad role in gene regulationPotential for developmental toxicity
Beyond the preview
Go deeper on Lysine Methyltransferase 2A (KMT2A).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Lysine Methyltransferase 2A (KMT2A).